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OPI de IsoPlexis

Опубликовано в Nextdoor OPI | Октябрь 2, 2012

OPI de IsoPlexis

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It was here that she developed her passion for applying computational chemistry and predictive modelling approaches for compound selection and design. Her particular interests lie in coupling machine learning and artificial intelligence techniques with generative chemistry approaches to explore chemistry space and guide compound design. Since , Tamsin has worked with scientific software providers supporting project teams and their use of computational and cheminformatics applications in drug discovery, enabling them to make informed decisions that will improve the efficiency and productivity of the drug discovery process.

Jeroen Overman received his PhD from the University of Queensland, Australia, where he investigated the role of transcription factors in aberrant cardiovascular growth and developed drug discovery projects against novel targets. He then joined Charles River Laboratories to drive mechanistic pharmacology and in vitro safety screening with a strong focus on high content imaging strategies.

In , he joined the department of Mechanistic Biology and Profiling at AstraZeneca, where he delivers profiling data with a deep mechanistic understanding for a wide range of early drug discovery projects across TAs. Neil is co-founder and Managing Director of Ziath. Within these companies Neil has been responsible for the development, maintenance and implementation of laboratory automation and associated software with a focus on process control and information management.

He was the informatics chair for Lab Automation , has edited for the Journal for the Association for Laboratory Automation and also served on the board of The Journal for Laboratory Automation. Having spent seven years in life science software services and then biotechnology leadership roles, Kate understands the varied needs of biotech companies and has learned a thing or two about how high quality data and user-friendly technology enable research discoveries and business intelligence.

User success has always been central to her methodology and she is passionate about driving engagement across all levels of an organization, from bench researchers to business leadership. After consulting with Third Rock Ventures portfolio companies for a year and helping launch companies with integrated and highly adoptable informatics platforms, Kate accepted a full time role at the Boston-based biotech startup MOMA Therapeutics as their head of informatics and technology.

Kate holds a BS in chemistry from Northeastern University and has completed multiple graduate level courses in topics spanning organic and bioanalytical chemistry to executive leadership and management. She also works closely with experimentalists in the Arkin lab to process, analyze and manage the data generated from high throughput screening at the Small Molecule Discovery Center at UCSF.

Peterson has more than 35 years of IT management experience focusing primarily on the verticals of laboratory operations and scientific instrument integration. During his career, he has worked for both private and public-sector organizations, including a stint as the CIO of the State Public Health Laboratory in Wisconsin, and has been directly involved with countless LIMS implementations and system integrations for a wide variety of laboratory operations.

In his role at Yahara Software, Mr. Peterson leads teams that provide innovative software solutions to support life science clients including efforts such as implementing laboratory systems at the CDC and working with organizations worldwide to support and enhance laboratory automation initiatives. When he is not spending time working on laboratory informatics, Garrett spends his free time operating pinball machines for various establishments in Madison and playing keyboards in a band.

Sridhar Iyengar, a serial entrepreneur, has revolutionized multiple industries. Sridhar holds over 50 patents and received his Ph. Beyond Elemental Machines, Sridhar has been known to run Dr Bayraktar is a neuroscientist interested in studying human brain development and disease. His technical interests are focused on high-throughput spatial genomics. His group has developed new computational tools to integrate single cell and spatial transcriptomics data for comprehensive mapping of cell types across complex tissues.

He had published in 30 publications and filed 3 US patents, with expertise in microbiology, diagnosis of infections, and antimicrobial discovery. He is a member of many international professional committees, such as the International Myeloma Working Group and the Asian Myeloma Network. He has authored more than publications in many reputed journals, and actively participates in clinical trials and has delivered talks in many national and international conferences.

In her years career at BD, Dr. Yu focused on innovation and technology development. She has been an active inventor herself with six issued patents and more than 10 pending. Yu joined Applied Cells in leading the activities in application development. He received a Ph. His current interest is focused on developing microtechnologies for single-cell and spatial omics profiling to interrogate functional cellular heterogeneity and inter-cellular signaling network in human health and disease e.

Wang specializes in the application of epigenomic technology platforms and interpretation of large-scale datasets to investigate human development and disease. He was previously a JDRF postdoctoral fellow at UC San Diego where his research focused on understanding pancreatic beta-cell development and diabetes by combining human genetics, stem cell differentiation, and epigenomics in the laboratory of Dr. Maike Sander. At the Center for Epigenomics, he currently oversees — including experimental design and data interpretation - multiple collaborative projects with investigators both in and out of San Diego, including projects focused on understanding human brain function using functional organoids, the molecular basis of human diseases such as diabetes and macular degeneration, and investigating lung cell-type diversity in the context of pedatric diseases such as BPD as part of LungMAP.

My academic and industrial expertise is focusd on drug delivery, nanomedicine, immunoengineering, and high-throughput analytical techniques for pharmaceutical and biotech applications. Currently I lead the high-throughput screening HTS and lab automation efforts to support the development of emerging drug delivery platforms and pharmaceutical formulations.

He received his undergraduate degree in mechanical engineering from Seoul National University, completed a Ph. His lab investigates microscale flows to develop a new class of microfluidic systems for biomedicine. She manages the target discovery and validation, and overseas the in vitro high throughput screening pipeline. In addition, she has extensive knowledge in building, optimizing, and validating high throughput in vitro screening automation system. She received a B.

Benedikt von der Heyde is a senior scientist at Pelago Bioscience. Anastasia Velentza is currently Senior Director, Platform Technology at Plexium, a Targeted Protein Degradation company focusing on the discovery and development of degrader drugs to address significant unmet medical needs.

Anastasia is a leader with multidisciplinary science background and more than 20 years of experience in Drug Discovery, with expertise in Assay Development, Screening, Pharmacology, and direction of cross-functional teams. Anastasia has worked in a variety of therapeutic areas spanning multiple molecular targets. Prior to Plexium, she worked at Ferring Pharmaceuticals serving as a Molecular Pharmacologist, Team Leader, and Head of Assay Development for lead generation in various disease areas, including Endocrinology, Hepatology and Gastroenterology.

Prior to that, she was a Research investigator at the Genomics Institute of the Novartis Research Foundation GNF , where she led biology and pharmacology efforts of scientific projects for multiple targets mainly in Oncology and Metabolic disease. Anastasia has received awards at national and international conferences for her research, which has been documented in more than 25 publications, patents, and abstracts. Jesse Chen, Ph. Jesse has more than a decade of discovery research and management experience, from early discovery through preclinical development.

Jesse also held research leadership roles at Moderna Therapeutics and Millennium Pharmaceuticals, where he was responsible for developing novel platforms and leading discovery programs. Jesse earned his Ph. Kleiger began his career as a structural biologist in the laboratory of Dr. Kleiger then joined the laboratory of Dr.

Ray Deshaies formerly Caltech and now Vice President of global research, Amgen focusing on the ubiquitin system and the application of biochemical and enzymological techniques to uncover enzyme mechanism. Kleiger is an expert in targeted protein degradation and a leader in the application of enzyme kinetics to the ubiquitylation reaction.

Kleiger's research is at the nexus of understanding how ubiquitylating enzymes function at the molecular level and how to harness the power of these enzymes to treat various human diseases such as cancer. He is involved in both academic and industry collaborations seeking insights into the targeted degradation of disease-causing proteins.

Kalli is a Principal Scientist at Mersana Therapeutics working on bioconjugation and antibody drug conjugates. Kalli has spent the past 15 years making antibody conjugates of all kinds at companies such as ImmunoGen, Amgen, and Mersana. There is a very good chance that she arrived here on a bicycle. Prior to joining CRL in I was a senior group leader at Takeda Cambridge with responsibility for assay development, in vitro pharmacology and hit ID activities.

My career in drug discovery started in a Wellcome Foundation funded lab at the ICR cloning novel kinase as potential breast cancer targets. Greg M. His work focuses on applying fundamental biotransport principles to design novel therapeutics and molecular imaging agents including antibody drug conjugates. He has authored over 50 papers and delivered 60 invited talks at major pharmaceutical companies, national and international conferences, and university departmental seminars.

Pettit Award for contributions to the field of antibody drug conjugates. He is currently a professor of Bioengineering. His research focus is on the developed experimental techniques for making highly quantitative measurements in single cells and models for linking those measurements to cellular function. His ultimate goal is to achieve a quantitative understanding of the molecular underpinnings of cellular behavior. He has co-authored more than peer-reviewed scientific publications and given over talks and keynotes.

Her research lies at the intersection of machine learning, statistics, and genomics, with a particular focus on computational models of genome packing and regulation. Her primary areas of research focus on biomedical data science and mobile health; her work includes wearable sensor, electronic health records, and multi-omics integration and digital biomarker discovery. Derek Janssens PhD is a postdoctoral researcher in the lab of Dr.

After completing his graduate thesis at the University of Michigan, Derek joined the Henikoff lab in and has been developing novel chromatin profiling tools to understand the epigenetic heterogeneity of cancer. Her lab focuses on implementing functional precision medicine approaches in clinical trials to improve treatment outcomes of cancer patients. Her research also investigates cancer stem cells and their role in therapy resistance and metastasis.

Her laboratory in the Department of Orthopaedic Surgery at UCLA couples basic research into mechanisms of disease to the development of novel therapeutic strategies. Her expertise lies in the development of tumor organoid models to investigate the biology of rare tumors and perform screenings for functional precision medicine applications. Thomas P. His efforts are focused on developing and applying cutting-edge applications and workflows in proteomics for cohort-scale analysis of clinically derived specimens.

The overarching goals of these efforts are toward identifying and validating protein biomarkers and surrogates for enhanced cancer patient management through improved early detection, patient stratification, and monitoring for therapeutic efficacy, outcome and recurrence. During this period, he started working with adult stem cell derived Organoid Technology and developed the first drug screens together with the group of Hans Clevers. She leads a multifaceted effort to translate breakthrough discoveries in stem cell biology and organ development into innovative organoid-based solutions to address unmet medical needs.

These include organoid-based platforms enabling discovery and development of safer and more efficient drugs, precision medicine applications and organoid-based therapies for end-stage diseases. This research has led to major advances in bioengineering of intestinal tissue by combining microchip manufacturing methods and organoid technology and demonstrated the utility of this platform in drug development, disease modeling and precision medicine.

She has authored numerous publications and patents. Heather Colvan is the cofounder and Director of Operations for Simplicis. Simplicis provides expert sample management solutions focused on data and hardware integration for automated pharmaceutical laboratories. For the past 12 years Heather has been focused on delivering problem specific solutions to Simplicis's clients with a dedication to data management.

Prior to Simplicis Heather worked in healthcare revenue cycle management implementing and integrating claims inventory management solutions. Heather is an advocate for women in computer science and gladly volunteers her time to facilitate a Girls Who Code club at her son's school. Shawnnah Monterrey, MBA, CEO of BeanStock Ventures, is a domain expert with over 20 years of experience in the medical industry with specific emphasis on guiding innovative products to market.

Shawnnah has a passion for innovation in medical devices, life sciences and biotechnology. As the CEO, she continues to provide thought leadership in guiding the innovation of products and services that benefit the market and healthcare. Maya is a rising Junior with a never ceasing curiosity for the world around her.

She was the team captain and programming lead on her FTC robotics team, and is currently their youth mentor. Maya has experience with android app development, computer vision, and machine learning. As Maya graduates High School and goes to college, she is always exploring every possible opportunity to learn and grow as both an engineer and a person.

Holistic diversity with all scientific application areas with knowledge of global best practices used in laboratories around the world. Joined BioDot in November While at Tecan, she was responsible for sales, marketing, applications, custom solutions, product development and worked with every facet of customer type and scientific application.

Early engineering, project management and technical sales roles provided Debbie with expertise in micro and macro filtration when working for Pall Gelman Sciences and Baker Hughes Process Equipment Company. Doug Densmore at Boston University. At the CIDAR lab, his research is focused on automating the design and fabrication of micro-environments to study the dynamics of intercellular communication and multicellular circuits in synthetic bacterial communities. At the DAMP Lab, he is responsible for supervising novel hardware, software, and wetware projects and managing off-the-shelf services and customer projects involving the design and assembly of synthetic genetic constructs using automated platforms.

Deepak Balaji is a chemical engineer by training and has worked on nanobiotechnology, industrial synthetic biology and drug screening for precision medicine. The work resulted in a Patent and sold as a product in a spin-out company. As a Senior Scientist at Oslo University hospital Norway, Deepak established the drug sensitivity screening platform for blood cancer precision medicine.

Deepak has published 32 research papers, 3 granted patents, 25 conference proceedings and book chapters. After graduation, he moved to Groningen for his PhD studies on microfluidic cell cultures and optical real-time cell monitoring. This work was performed with professor Verpoorte, in the Pharmaceutical Analysis group. It was also part of a larger EU collaborative network LiPhos , which aimed to design, develop and test an optical tool for endothelial cell behaviour.

Prior to this Dr Stoten worked in healthcare consulting and then in increasingly senior commercialisation roles at Isis Innovation. Dr Stoten also serves as a board member of both PraxisAuril, the UK professional association for knowledge exchange practitioners, and of ATTP, the body that maintains internationally recognised standards for the knowledge and technology transfer profession. My personal expertise lies within the early stage, life sciences and high- and deeptech domain. Maurizo Aiello, CEO of React4life with international experience in company growth, execution, innovation.

Specialties are: strategic vision and ability to create innovation, starting from basic and applied research and reaching the market. At present, he launched 3 startups born from basic research. He holds a physics degree in nuclear physics in Author of more than 60 articles in international journals, international conferences, white papers; research activity in bioengineering, cybersecurity and infrastructure management.

Hacker, with competences in development of cyberattacks and cyberweapons to IoT devices and networking infrastructure. Amel Bendali, PhD, is the Chief Operating Officer and co-founder of Inorevia, a Paris-based startup providing new tools for life science research and diagnostics. After graduating as an engineer in Physics and Biotechnologies, she joined the Vision Institute in Paris to participate in an ambitious research project to develop retinal prosthetic implantable devices, helping to restore functional vision to blind patients.

Since the creation of Inorevia in , Amel has gained extensive experience in entrepreneurship, market approach for innovation, and taking patents and invention to meet market needs and solving actual users challenges. Inorevia's vision is to unlock next-generation life science solutions, by combining highly efficient miniaturization and full automation to support reasearchers and clinicians dealing with complex workflows and challenging samples. She is currently developing high content imaging assays using iPSC-derived neurons and iNeurons from healthy and Alzheimer's disease patients.

She has worked in the drug discovery field for over 20 years in academia and in industry. After extensively training in Indian classical, folk, and hip hop dance in NJ, Ishita founded to use her cultural roots to share global stories with artists of diverse backgrounds. Lab automation engineer and molecular biologist specialized in scaling, development, and teams. Extensive knowledge of molecular biology high throughput laboratory systems and CLIA lab operations, analytical assay validation and clinical studies to supporting clinical utility for LDTs.

Enthusiastic about learning and enabling tools and solutions contributing to the improvement of human health. Ashley J. Wallace, Ph. Joshua Goldberger. Upon completing her doctoral program, she realized her desire to combine her love for science with general education.

In her current position, Dr. She is also heavily involved in the development and implementation of policies that support diversity initiatives and fosters a culturally inclusive scientific community. Aiming to promote and increase public awareness of STEM relevance in society to communities that are disproportionally underserved, Dr. In , Dr. Peter E.

Wais, Ph. After a career in industry, which culminated as chief executive for companies producing basic sheet steel and pure chocolate, I redirected my energy and curiosity toward basic research in the cognitive neuroscience of long-term memory. I made the transition from leadership of an industrial organization to graduate school at UCSD, where I developed my thesis in cognitive neuroscience about the roles of the hippocampus in recognition memory.

My current research focus involves a translational neuroscience approach in a cognitive training intervention that targets sustained improvement in capabilities for long-term memory LTM and cognitive control. My goal in this research is to develop an effective, practically useful cognitive intervention that remediates high-fidelity LTM capabilities in older adults diminished by mild cognitive impairment MCI. In his role he supports clinical stage drug programs with aspects of their digital strategy that focus on remote clinical data collection using devices and wearable sensors.

Tim's academic training was in Mechanical B. S and Biomedical Ph. His current focus is on developing and implementing digital health technologies to collect key clinical trial endpoint data in order to increase efficiency in clinical development. She is founder and chief scientist of React4life s. Scaglione is author of more than 80 international peer-reviewed papers, book chapters, author of 7 patents.

At DiMe, she curated scientific content, led patient engagement and equity initiatives, and developed content for the Playbook, the essential industry guide for developing successful digital clinical measures. Prior, she supported the digital clinical team at MindMedicine, developing successful digital, remote data capture paradigms supporting psychadelic drug development.

Before that, she was in the Digital Medicine group at Pfizer exploring innovative technological approaches to drug development, including developing the industry-first on-site lab using digital medicine tools wearables, ambient sensors, etc. Rachel is based in Chicago, USA.

Daniel has more than years of experience in the biopharma industry, working across multiple functional disciplines, including phenotypic assay development, high-throughput screening, and software engineering. His research focused on developing novel phenotypic assays across a wide range of indications.

Daniel received a B. Charles Fracchia is the founder of BioBright, a Boston-based company that automates the secure data collection and analysis from laboratory and biomanufacturing environments. BioBright was initially funded by DARPA to create DarwinSync: the first -and continues to be the only- scalable and end-to-end encrypted data collection and analytics system for the life sciences market. Fracchia is also the Co-Founder of BIO-ISAC, an international organization that addresses threats unique to the bioeconomy and enables coordination among stakeholders to facilitate a robust and secure industry.

Charles gained critical experience from his work at IBM Research and Ginkgo Bioworks where he was respectively the first synthetic biologist and first full-time person outside of the founding team. A successful Computational Biology researcher will have a strong understanding of computational techniques and the biological processes and techniques underlying the development of the data they are analyzing.

In the courses Joshua teaches at Carnegie Mellon University, students generate experimental data in wet-lab experiments and learn to apply computational techniques for the analysis of those data. Joshua constantly looks for ways to make our course offerings as modern as possible in both the wet-lab and computational techniques learned by students. At times, this has included modernizing classic labs or generating new modules based on novel research. He teaches courses for high school students, undergraduates, and graduate students M.

He was also integral in the design and setup of the Automation Lab used by the M. Automated Science program at Carnegie Mellon University. Brian joined HighRes in March as the head of sales and marketing. Brian has more than 20 years experience selling, marketing, demonstrating, breaking, servicing lab automation solution. The solutions range from basic liquid handling workstations to enterprise level modular, mobile robotic automation data factories.

Toby Blackburn serves as the Head of BD and Strategy at Emerald Cloud Lab ECL , a physical laboratory which scientists can access remotely via the internet that allows them to run, analyze, and interpret experiments without setting foot in the lab. David R. Walt is the Scientific Founder of Illumina Inc. He has received numerous national and international awards and honors for his fundamental and applied work in the field of optical microwell arrays and single molecules.

He is a member of the U. National Academy of Engineering, the U. Raven's mission is simple-- to solve for racial inequity by breaking down generational and racial barriers in the workplace, replacing them with empathy and synergy that fosters productive working relationships, drives business results, and prepares organizations to compete in the not-so-distant future. In her spare time, Raven consults with Franklin Covey, the world leader in leadership development, in the area of unconscious bias and is the host of The Generational View Podcast.

Raven has helped tens of thousands, from podiums around the world, close the gaps inside of dozens of industry-leading companies, and create sustainable cultural change. As the valedictorian of her college graduating class and one of the youngest-ever executives in the Fortune 50 company with which she spent nearly a decade, she has always shown that her approach to leading and influencing people yields results.

Her research focuses on profiling changes in cell surface glycosylation associated with cancer, inflammation and infection, and exploiting this information for development of diagnostic and therapeutic approaches, most recently in the area of immuno-oncology. Please Login Log In. Already registered? Log in now. Jefferson Chin, B. Josephine Bunch. Martin Giera, Ph. Markus Schirle, Ph.

Judith Wardwell-Swanson Sr. Woojung Shin Postdoctoral Fellow Wyss Institute At Harvard University I am a biomedical engineer and scientist with expertise in developing microphysiological human organ-on-a-chip platforms. Caroline Sartain Sr. Scientist Fulcrum Therapeutics Caroline Sartain is a Senior Scientist in Fulcrum Therapeutics' Target Discovery group where she specializes in next-generation sequencing-based assays for drug discovery.

Rohit Arora Application Scientist Iktos Inc Rohit Arora is an Application Scientist at Iktos where he works on collaborations with, and deployment of Iktos software to, pharmaceutical and biotech clients. Katelyn Hardy Director, Informatics and Technology MOMA Therapeutics Having spent seven years in life science software services and then biotechnology leadership roles, Kate understands the varied needs of biotech companies and has learned a thing or two about how high quality data and user-friendly technology enable research discoveries and business intelligence.

Sridhar Iyengar, Ph. Omer Bayraktar Group leader Wellcome Sanger Institute Dr Bayraktar is a neuroscientist interested in studying human brain development and disease. Aram Chung, Ph. Kalli Catcott Sr. Scientist Mersana Therapeutics Kalli is a Principal Scientist at Mersana Therapeutics working on bioconjugation and antibody drug conjugates. Heather Colvan, Ph.

Debbie Bowers, M. Mitchell Mutz, Ph. He is currently an entrepreneur partner at Vivo Capital, a fund focused on investment opportunities in therapeutics, medical devices, and tools. Previously, Mitchell was a co-founder, president, chief scientific officer, and board member of Amplyx Pharmaceuticals, Inc. Amplyx had a successful Phase 2 clinical trial readout in and was acquired by Pfizer in Mitchell was also on the founding team and the Principal Scientist of Labcyte, a tools company that he helped grow from a garage-based start-up to profitability.

Mitchell was responsible for discovering and and developing biotechnology applications for Labcyte's novel acoustic drop ejection technology. Mitchell earned a Ph. Mitchell is also an inventor on 37 issued patents. Ashley Wallace, Ph. Silvia Scaglione, Ph. Chief Scientist React4life She received in the Ph. Daniel R. Joshua Kangas, Ph. Assistant Teaching Professor Carnegie Mellon University A successful Computational Biology researcher will have a strong understanding of computational techniques and the biological processes and techniques underlying the development of the data they are analyzing.

Walt, Ph. Key: Complete. Opening Keynote Presentation: Therapeutic opportunities in glycoscience. Open to view video. Cell surface glycans constitute a rich biomolecular dataset that drives both normal and pathological processes. Our recent efforts center on pathogenic glycans in the tumor microenvironment and new therapeutic modalities based on the concept of targeted degradation.

You must register to access. In this informative and inspiring keynote, Raven breaks down the connection between equity and generations that every organization needs to know and lean into to thrive in a marketplace that is growing more racially and ethnically diverse by the decade.

She helps attendees of all backgrounds understand how and why a generation can impact how they view, understand, and even combat racism. Attendees will leave with greater clarity on the role their generation can play in fighting for racial equity, and how to effectively collaborate with other generations in that pursuit.

Biomarker discovery, however, is only the beginning of the process. Biomarkers must be validated and methods must be developed for measuring them reproducibly with sufficient throughput to be used in both research and the clinic. The development of new biomarker technology platforms for both discovery and wider implementation involves automation and scaleup to enable biomarker use in research, drug development, and clinical diagnosis.

Advances in Bioanalytics and Biomarkers. The incorporation of electrospray ionization ESI -based mass spectrometry MS into the portfolio of high-throughput capable readout technologies has historically been hampered by the lack of suitable interfaces delivering the sample to the ESI ion source. Here, classical approaches face different bottlenecks such as limited sampling speed, analyte carry over, sample consumption, as well as the need for laborious sample preparation.

The introduction of acoustic ejection mass spectrometry AEMS has provided an elegant solution by combining fast and contactless acoustic sampling with sensitive and accurate MS-based analyte detection. Our investigations on this novel technology resulted in two cutting-edge setups.

First, a breadboard system combining a generic acoustic droplet ejection ADE system with an open port interface OPI was used to capture nanoliter droplets directly ejected from microtiter plate wells and to transport these to the ESI-source for MS analysis. This system was used to assess and optimize critical performance parameters related to analytical throughput and system stability. Maximum achievable sampling rates of up to 6 Hz are demonstrated for various ADME assays together with stress tests regarding ion suppression and system robustness.

This was achieved by combining custom software interfaces, in-house hardware modifications, and learnings from a validation project aiming at the identification of inhibitors of the cyclic GMP-AMP synthase cGAS. We describe the method optimization to enable sensitive and accurate determination of enzyme activity and inhibition in a miniaturized well microtiter plate format. Furthermore, we present results from both a validation single-concentration screen using a test set of 5, compounds, and the subsequent concentration-response testing of selected hits in direct comparison with a previously established MALDI-TOF readout.

In agreement with our observations on the breadboard system, passive and active cleaning options are demonstrated to effectively remain optimum system performance during HTS campaigns or to recover the ready state of the system after a blocked OPI from samples with high matrix loads. Compound Management CMD has the responsibility to oversee the Pfizer compound collection and ensure that the integrity of the collection is of high quality. The throughput of sQC is driven by two factors, the number of compounds in the queue and the instrumentation available.

The current sQC operations were designed to support lead optimization activities, where the number of active compounds range in the hundreds. High-Throughput screening activities, however, can have compound queues in the thousands which can overburden the sQC process. Acoustic Ejection Open Port Interface Mass Spectrometry AE-OPI-MS employs acoustic dispensing technology to introduce samples to the mass spec alleviating the chromatography requirement while increasing the rate of analysis over 3fold.

AE-OPI-MS methodology has been developed to complement the traditional sQC analysis and expand the analytical capabilities to support high throughput screening. Software improvements were also developed to enable the analysis to include purity assessment.

Coordinated automation to support biomarker discovery using machine learning. Additionally, unbiased discovery necessitates consideration of a large number of input variables from each sample, while minimizing required sample volumes. All of these issues must be considered to avoid constraining model development due to insufficient power. Working with Hamilton Storage, we designed a high-capacity automated sample storage, retrieval, and processing pipeline for aliquoting and analysis of the study samples.

To measure the miRNAs, we worked with Abcam, Inc to design a custom panel of microRNA probes using the Fireplex particle technology, a porous bio-inert hydrogel that allows target capture throughout the 3D volume with spatial resolution to cover 68 distinct microRNAs per 50 ul sample well.

Samples were subaliquoted into low profile 0. With full implementation of the system, we are now completing circulating miRNA profiles of study subjects per week, which comprises 36, separate data points, and we will complete the 10,patient cohort in just over a year. Conclusions A coordinated approach to sample identification, inventory management, and high dimensionality analysis is required to use machine learning approaches to biomarker discovery.

Automating each step of the process increases efficiency while allowing accurate sample tracking and maximization of each sample. Gefitinb, an anilinoquinazoline inhibitor of thymidylate kinase selective for the epidermal growth factor receptor EGFR , was originally developed as a treatment for non-small cell lung cancer. The addition of an IM separation gave rise to much improved MS data thereby aiding the identification of several novel glucuronide metabolites. Changes in endogenous metabolite profiles, both increases and decreases in amounts, appeared shortly after dosing and had largely returned to their predose values by 24hrs.

The changes in the amounts of endogenous metabolites excreted in the urine mirrored to some extent the plasma pharmacokinetics of the drug demonstrating a possible pharmacometabodynamic effect. This type of combined drug and endogenous metabolite profiling may this represent a method for better understanding the pharmacology of drugs in terms of the way that their effects modulate the metabolic pathways of the organisms exposed to them, including patients.

A fluorogenic tripeptide substrate was used to develop and validate biochemical screening assays for identification of TMPRSS2 inhibitors. Herein we compare label and label-free detection methods with respect to analytical performance, cost, and routine usage in context of a screening campaign using two TMPRSS2 peptides as marker substrates.

In this lecture we will give an overview of recent developments in targeted and untargeted metabolomics and lipidomics analysis. Pitfalls and challenges for implementing metabolomics and lipidomics in drug discovery will be discussed.

Showcasing specific examples, the use of lipidomics and metabolomics for target discovery, mode of action and physiological response marker elucidation will be explained. Next to a general introduction to the topic we will specifically focus on non-alcoholic steatohepatitis NASH and the use of lipidomics technologies.

Showing data from one of our chemical probes in a humanized preclinical mouse model we will discuss the application of lipidomics and metabolomics starting with screening in a whole cell assay, followed by the definition of physiological response and target engagement markers and finally deciphering the mode of action. Target deconvolution using compressed cellular thermal shift assay cCETSA influences key project decisions. Although affinity pull down approaches have greatly expanded our knowledge of drug targets, derivatization of the drug requires domain expertise in medicinal chemistry.

Furthermore, affinity pull downs are not feasible when a drug molecule has a steep SAR that precluded linker attachment or lack of chemistry resources. The method is increasingly being employed both in mechanism of action MoA studies and to identify primary and off-targets of candidate drug molecules.

Here we would like to present the application of cCETSA in AstraZeneca for compounds at various project stages like phenotypic HTS hit, candidate identification drug, lead optimisation identification drug, literature compounds there by influencing key project decisions. Metabolites are involved in every aspect of biology, and since the metabolome is highly dynamic in nature and a sensitive indicator of phenotype, we can take advantage of this to identify metabolic markers to be applied for treatment response in drug discovery.

Metabolomics-based drug discovery presents therefore an exciting challenge for MS analysis as the system becomes inherently more complex. Herein, we apply this technology for cellular assays, specifically to detect metabolites and lipids in a comprehensive, untargeted, and unbiased HTS approach for drug discovery in idiopathic pulmonary fibrosis IPF.

Multiple IPF-relevant stimuli and inhibitors were tested to see if stimulation and inhibition could be distinguished in the assay. Next, different sample preparation conditions, such as testing different matrices, additives, derivatization reagents, and extraction protocols, were investigated to ensure the most effective analysis for metabolites and lipids.

All the parameters were optimized using Mosquito-TTP Labtech liquid handling robot to allow a systematic screening of a large number of combinations to find the best conditions. Moreover, all the protocols were simplified and adapted to HTS compatible platforms to ensure a smooth translation from an academic laboratory to industry. Using principal component analysis PCA , hierarchical clustering, and machine learning strategies, a subset of peaks was identified to be unique to each condition.

This data supports that it is possible to elucidate important metabolic features of cells in modelled pathophysiology. This approach has the potential to be further optimized as an automated HTS drug discovery assay in the industrial setting. Assay Development and Screening Innovation Award. The biological basis behind these variations is still not well understood, but a growing body of literature has alluded to certain T-cell functional properties such as high proliferative potential and propensity to secrete multiple cytokines simultaneously as key drivers of response.

However, tools to analyze and select populations of cells based on functional properties, such as secreted products, are critically lacking. Current immune cell phenotyping approaches are limited by heavy reliance on screening differentially expressed surface receptors which fails to describe their functional potency.

Therefore, there is a critical need to develop new platforms to sort based on cell function, such as level and types of secreted cytokines to identify gene expression signatures associated with functional responses, uncover cell surface markers that are more descriptive of optimal functional phenotypes, or directly sort starting cell populations with higher therapeutic potential during manufacturing of cell therapy. Here, we report a workflow for the rapid screening and sorting of individual T-cells based on secreted factors that are accumulated on 3D-structured microparticles using a standard fluorescence activated cell sorter FACS.

Our cavity-containing hydrogel microparticles nanovials can be loaded with single T-cells and encapsulated into uniform droplets by simple pipetting steps to confine secreted cytokines for capture on the particle. By gating on a combination of fluorescence area and height parameters, we can differentiate secreted cytokine signal on nanovials from signal solely from presumably permeabilized or dead cells. Cells also maintained their viability after sorting, in which they can be further analyzed for their growth and functionality post-sort.

Our technology can quantitatively screen and sort potentially millions of viable cells based on their cytokine secretion levels, which will aid in discovery of T-cell receptors and surface markers responsible for robust functional responses, improving upon the current paradigm of cell therapy.

This type of cancer begins with healthy cells that change and start growing out of control forming lesions or tumors. Understanding the dynamics of how the tumor microenvironment promotes the cancer initiation and progression that will lead to the cancer metastasis is crucial to help in the process of identifying new molecular therapies. Primary cell 3D cell culture models have received renewed recognition not only due to their ability to better mimic the complexity of in vivo tumors as a potential bridge between traditional 2D culture and in vivo studies.

NPs are typically not very well represented in the current drug discovery libraries and can provide a new insight to discover leads that could potentially emerge as novel molecular therapies. After further evaluation, the selected active NPs identified were prioritized to be screened against all 10 NSCLC cell lines as concentration response curves to determine the efficacy and selectivity of the compounds between wild type and mutant 3D cell models.

Here, we demonstrate fully automated 3D screening using natural products that may identify NPs from microorganisms that can provide a future use toward human cancer. A coculture platform to screen therapeutic bacteria within tumor spheroids. The prevalence of tumor-colonizing bacteria has spurred new research directions including the engineering of bacteria to locally deliver therapeutics to tumor environments.

However, a central challenge for translating this next-generation therapy to clinics is the lack of tools to identify potent therapeutic strains in tumor environment. Thus, the vast majority of the past studies have relied on animal models that only test a handful of therapeutic candidates.

To address this challenge, we developed a novel 3D multicellular coculture platform that enables parallel and continuous culture of diverse bacteria in tumor spheroids, recapitulating selective bacterial growth in solid tumor. Leveraging the high throughput nature of the platform, we screened a library of therapeutic bacteria expressing cytotoxic molecules. We identified novel therapeutic bacteria that significantly reduced tumor size and validated similarities in efficacies using a syngeneic mouse model.

Utilizing the stability of the multicellular culturing system, we also tested the performance of engineered bacterial biosensors in a physiological environment. We constructed oxygen, pH and lactate sensors that controls bacterial growth, and confirmed their activities in tumor spheroids. This approach identified a strain that reduced off-target colonization in an animal model.

These approaches can be utilized towards accelerating the development of therapeutic bacteria for clinical applications. Adding Dimensions to Multiplex Molecular Imaging. However, imaging approaches are challenged by major tradeoffs between spatial resolution, temporal resolution, field of view and the limited photon budget.

We are attempting to advance this tradeoff by constructing faster and more efficient light sheet microscopes that maintain subcellular resolution. Our two-photon light-sheet microscope combines the deep penetration of two-photon microscopy and the speed of light sheet microscopy to generate images with more than ten-fold improved imaging speed and sensitivity.

As with other light sheet technologies, the collection of an entire 2-D optical section in parallel dramatically speeds acquisition rates. By adopting two-photon excitation the light sheet illumination is far less subject to light scattering, permitting subcellular resolution to be maintained far better than conventional light sheet microscopes. This combination of attributes permits 4D cell and molecular imaging with sufficient speed and resolution to generate unambiguous tracing of cells and signals in intact systems.

To increase the 5th Dimension, the number of simultaneous labels, we are refining new multispectral image analysis tools that exceed the performance of our previous work on Linear Unmixing by orders of magnitude in speed, error propagation and accuracy. These new analysis tools permit rapid and unambiguous analyses of multiplex-labeled specimens.

In parallel, we have refined label-free approaches so that imaging and sensing can be more extended to patient-derived tissues and even human subjects. The low concentrations and low sensitivity of the techniques can make single cell approaches challenging. We have refined fluorescence lifetime approaches FLIM , combining it with multispectral tools to optimize intravital imaging in these challenging settings.

Combined, these imaging and analysis tools offer the multi-dimensional imaging required to follow key events in intact systems as they take place, and to allow us to use noise and variance as experimental tools rather than experimental limitations. Base editing screens to define drug-target interactions. CRISPR technology has enabled the manipulation of genetic information with tremendous scale and flexibility.

Here we will present screens utilizing Base Editor technology, which enables amino-acid-level resolution of drug-target interactions. Such screens can be used to identify a resistance mutation that helps to prove the actual target of a less-characterized small molecule.

Additionally, this approach can provide insight into potential resistance mechanisms long before seeing what arises in patients. The low upfront costs of generating a pooled, base editing library, coupled with the small-scale and relative ease of execution, argues for applying this technique early in the drug discovery process. Binding site hotspot mapping with photo-affinity labeling. All biological processes are governed by chemical signals relayed through protein networks. These small molecule signals can inhibit, enhance, or impart new functions to proteins through direct associations to binding sites on a protein that drive alteration of the broader proteomic network.

To discover binding site hotspots in the global proteome, we developed a chemical proteomics platform termed small molecule interactome mapping by photo-affinity labeling SIM-PAL. SIM-PAL uses a small molecule carrying a photo-affinity label to capture molecular interactions within the global proteome. After treatment of live cells with the small molecule, the resulting interactions are captured by photochemical conjugation and affinity enriched. The enriched proteins are identified by proteomics and the exact binding sites are mapped by isotope-targeted mass spectrometry MS.

Isotope-targeted MS enables the selection of small molecule-linked peptides, representing binding sites, against a background of unlabeled peptides for high-confidence identification of the underlying molecular structure. SIM-PAL combines phenotypic cellular assays with high-resolution structural measurement of where and when a small molecule is binding throughout the whole proteome using the discovery power of MS.

Applications of SIM-PAL to bioactive small molecules and the structural implications of binding site hotspots from photo-affinity labeling chemistry will be described. Biochemical and biophysical approaches for accelerating the discovery of small molecules for differentiation targets.

Chemogenomics interrogation of modulators of intestinal fibrosis using a multiparametric imaging- and biomarker-based approach. Intestinal fibrosis is a common complication of several enteropathies with inflammatory bowel disease being the major cause.

The progression of intestinal fibrosis may lead to intestinal stenosis and obstruction. Even with an increased understanding of tissue fibrogenesis, there is no approved treatment for intestinal fibrosis. AXL 0. HCI 0. SCU 0. BZH 0. APTS 0. FISI 0. ACBI 0. CSV 0. CPSI 0. OIS 0. HAYN 0. NESR 0. AVD 0. CCNE 0. ANIP 0. PFIS 0. UFI 0. NNBR 0.

OAS 0. MPB 0. CWST 0. PKOH 0. RCII 0. WETF 0. NSTG 0. FRGI 0. CVGI 0. TAST 0. IEA 0. PARR 0. TBK 0. TEN 0. UIHC 0. BFS 0. AOSL 0. LTRPA 0. Live Nation Entertainment, Inc. Equity Lifestyle Properties Inc. Lions Gate Entertainment Corp. Braemar Shipping Services plc. Selective Insurance Group Inc. Healthcare Realty Trust Incorporated.

Altra Industrial Motion Corp. Portland General Electric Company. Pacific Biosciences of California Inc. Madison Square Garden Entertainment Corporation. Chimera Investment Corporation. Essential Properties Realty Trust Inc. Turning Point Therapeutics Inc. National Health Investors, Inc. Atlantic Union Bankshares Corp. California Water Service Group. Madison Square Garden Sports Corp. Sunnova Energy International Inc.

Brookfield Infrastructure Corp. Prestige Consumer Healthcare Inc. Allscripts Healthcare Solutions, Inc. Retail Properties of America Inc. Piedmont Office Realty Trust, Inc. Innovative Industrial Propertes Inc. Retail Opportunity Investments Corp. Washington Real Estate Investment Trust. Atlas Air Worldwide Holdings, Inc. Easterly Government Properties Inc. Industrial Logistics Properties Trust. Ligand Pharmaceuticals Incorporated.

Argo Group International Holdings Ltd. PennyMac Mortgage Investment Trust. Northwest Natural Holding Company. Monmouth Real Estate Investment Corp. Shenandoah Telecommunications Company. Horace Mann Educators Corporation. Office Properties Income Trust. Stewart Information Services Corporation. Tanger Factory Outlet Centers Incorporation.

Enterprise Financial Services Corp. Air Transport Services Group Inc. Bottomline Technologies DE Inc. Constellation Pharmaceuticals Inc. Schnitzer Steel Industries Inc. Boston Private Financial Holdings Inc. Healthcare Services Group Inc. Centennial Resource Development Inc. Allegheny Technologies Incorporated. Apartment Investment and Management Company. Donnelley Financial Solutions Inc. Federal Agricultural Mortgage Corporation.

Clear Channel Outdoor Holdings, Inc. Helix Energy Solutions Group, Inc. New Senior Investment Group Inc. Granite Point Mortgage Trust Inc. Aerojet Rocketdyne Holdings Inc. NexTier Oilfield Solutions Inc. Arcturus Therapeutics Holdings Inc. Urstadt Biddle Properties Inc. Radius Global Infrastructure Inc. Consolidated Communications Holdings Inc. Central Pacific Financial Corp. Comtech Telecommunications Corp.

Peapack-Gladstone Financial Corporation. National Western Life Group Inc. United States Cellular Corp. Sculptor Capital Management, Inc. Diamond Hill Investment Group Inc. Preferred Apartment Communities, Inc. Atlantic Capital Bancshares, Inc. Computer Programs and Systems, Inc. Assetmark Financial Holdings Inc. Community Healthcare Trust Inc. Capstar Financial Holdings Inc. James River Group Holdings Ltd. National Energy Services Reunited Corp. Hingham Institution for Savings.

Entravision Communications Corporation. Ryman Hospitality Properties Inc. Universal Insurance Holdings Inc. Corporate Office Properties Trust. American National Bankshares Inc. Tonix Pharmaceuticals Holding Corp. State Auto Financial Corporation. Bluegreen Vacations Holding Corp. Solaris Oilfield Infrastructure Inc. Heritage Insurance Holdings Inc. Nature's Sunshine Products Inc. Infrastructure and Energy Alternatives, Inc.

United Insurance Holdings Corp. Natural Grocers By Vita Cottage. Houghton Mifflin Harcourt Company. Universal Logistics Holdings Inc. Advent Technologies Holdings Inc. Independent Bank Corp. Group 1 Automotive, Inc.

Applied Therapeutics Inc. Werner Enterprises. Acushnet Holdings Corp. Agree Realty Corp. Vor BioPharma Inc. Thermon Group Holdings Inc. Trinity Industries, Inc. InterDigital, Inc. Chesapeake Utilities Corporation. First Advantage Corp. Realogy Holdings Corp. Oil-Dri Corp of America. Liberty Latin America Ltd. West BanCorp Inc. Hancock Whitney Corporation.

Atn International Inc. Galaxy Digital Holdings Ltd. Athira Pharma Inc. Oxford Industries, Inc. Equity Bancshares Inc. Southern First Bancshares Inc. Koppers Holdings Inc. Hawaiian Holdings Inc. Resideo Technologies Inc. Prometheus Biosciences Inc. Ethan Allen Interiors Inc. Intrepid Potash Inc. Lakeland Bancorp, Inc. Meridian Bioscience Inc. Cal-Maine Foods Inc. Ares Commercial Real Estate Co. Aviat Networks Inc.

Meritage Homes Corp. Triumph Group Inc. HarborOne Bancorp Inc. Target Hospitality Corp. Spirit Airlines Inc. Generation Bio Co. Atlas Technical Consultants Inc. Omega Therapeutics Inc. Reneo Pharmaceuticals Inc. Cadence Bancorporation. Hyliion Holdings Corp. Adagio Therapeutics Inc. Tootsie Roll Industries Inc. Boston Omaha Corp. ChannelAdvisor Corp. Whiting Petroleum Corporation. Mercantile Bank Corp. Northwest Pipe Co. Camden National Corporation.

Brookline Bancorp, Inc. Ingles Markets, Incorporated. Integer Holdings Corporation. Sight Sciences Inc. Glacier Bancorp Inc. Investors Bancorp Inc. Oppenheimer Holdings Inc. Flagstar Bancorp, Inc. Northwest Bancshares Inc. Standex International Corp. Varex Imaging Corporation. Jack in the Box Inc. E2open Parent Holdings Inc. Option Care Health Inc. Universal Health Realty Income Trust. Bjs Whsl Club Hldgs Inc. Financial Institutions, Inc. Spero Therapeutics Inc. Blue Ridge Bankshares Inc.

Hilltop Holdings Inc. Utah Medical Products Inc. Integral Ad Science Holding Corp. United Natural Foods, Inc. Regional Management Corp. Tilly's Inc. El Pollo Loco Holdings Inc. Syros Pharmaceuticals Inc. Diversified Healthcare Trust. MeiraGTx Holdings plc. Standard Motor Products, Inc. Dyne Therapeutics Inc. Vera Therapeutics Inc. Mesa Air Group Inc. Scorpio Tankers Inc. Arena Pharmaceuticals Inc. DiamondRock Hospitality Co. Rhythm Pharmaceuticals Inc.

Urban Outfitters Inc. Old National Bancorp. Aerovate Therapeutics Inc. Park-Ohio Holdings Corp. Poseida Therapeutics Inc. Radiant Logistics Inc. PDF Solutions Inc. Banc of California Inc. Design Therapeutics Inc. Superior Group of Cos Inc. Kura Oncology Inc. American Superconductor Corp. Washington Federal Inc. Comstock Resources Inc. Bridgewater Bancshares Inc. Northfield Bancorp Inc. World Acceptance Corporation.

Employers Holdings Inc. Titan International Inc. TriState Capital Holdings Inc. Tarsus Pharmaceuticals Inc. Constellium SE. Vishay Intertechnology, Inc. Glatfelter Corporation. Apple Hospitality Reit Inc. Universal Electronics Inc. Angel Oak Mortgage Inc. Chesapeake Energy Corporation. Nurix Therapeutics Inc. Sunpower Corporation. Pliant Therapeutics Inc. Navient Corporation. Caribou Biosciences Inc. Dynex Capital Inc. Orchid Island Capital Inc.

Outfront Media Inc. PS Business Pks. Century Therapeutics Inc. Invesco Mortgage Capital Inc. Trillium Therapeutics Inc. Texas Pacific Land Corp. Warrior Met Coal Inc. Merit Medical Systems Inc. Chuy's Holdings Inc. Kiniksa Pharmaceuticals Ltd. Capital City Bank Group Inc.

Alpha Teknova Inc. Southern Missouri Bancorp Inc. Associated Capital Group Inc. Gladstone Commercial Corporation. Lazydays Holdings Inc. Independence Holding Co. Allogene Therapeutics Inc. Eiger BioPharmaceuticals Inc. American Public Education Inc.

Rayonier Advanced Materials Inc. Rain Therapeutics Inc. Haynes International, Inc. HighPeak Energy Inc. Revolve Group Inc. Equity Commonwealth. Lantheus Holdings Inc. Werewolf Therapeutics Inc. Frank's International NV. Recursion Pharmaceuticals Inc.

Old Second Bancorp Inc. OraSure Technologies Inc. Strategic Education Inc. Newpark Resources Inc. Olema Pharmaceuticals Inc. Community Health Systems Inc. Mueller Water Products, Inc. DigitalBridge Group Inc. Blueprint Medicines Corporation. Atara Biotherapeutics Inc. Mid Penn Bancorp, Inc. Midland States Bancorp Inc. Gp Strategies Corporation. American Finance Trust Inc. TCR2 Therapeutics Inc. Myriad Genetics Inc. Saul Centers, Inc. Seritage Growth Properties. Xperi Holding Corporation.

Southside Bancshares Inc. Bryn Mawr Bank Corp. Rapid Micro Biosystems Inc. Rekor Systems Inc. Seaspine Holdings Corp. Reata Pharmaceuticals Inc. Wheaton Precious Metals Corp. Taylor Morrison Home Corp. Repay Holdings Corporation. Summit Financial Group Inc. Ormat Technologies Inc. Universal Corporation. Amalgamated Financial Corp. Amerant Bancorp Inc.

Mistras Group Inc. Maiden Holdings Ltd. Theravance Biopharma Inc. Mueller Industries Inc. Biglari Holdings Inc. Macatawa Bank Corp. Commercial Vehicle Group, Inc. Watts Water Technologies Inc. Range Resources Corp. Hersha Hospitality Trust. Carter Bankshares Inc. Emerald Holding Inc. Hyster-Yale Materials Handling, Inc. OceanFirst Financial Corp. Scholastic Corporation. CrossFirst Bankshares Inc. Kimball Electronics Inc. Barrett Business Services Inc. Kelly Services Inc. Ping Identity Holding Corp.

Cathay General Bancorp. Viavi Solutions Inc. New York Mortgage Trust, Inc. Turtle Beach Corporation. Columbus McKinnon Corporation. Business First Bancshares Inc. Oasis Petroleum Inc. Ideaya Biosciences Inc. Ellington Financial Inc. AgEagle Aerial Systems Inc. Cytek Biosciences Inc. Gray Television, Inc. National HealthCare Corp. MVB Financial Corp. Landsea Homes Corp.

Lineage Cell Therapeutics Inc. Sera Prognostics Inc. ICF International Inc. Patterson Cos Inc. Vivint Smart Home Inc. Sutro Biopharma Inc. Metrocity Bankshares Inc. MultiPlan Corporation.

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